Human MKK6 / MEK6 / MAP2K6 Protein (His & GST Tag)

MAPKK6,MEK6,MKK6,PRKMK6,SAPKK-3,SAPKK3

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Catalog Number	P10422-H20B
Organism Species	Human
Host	Baculovirus-Insect Cells
Synonyms	MAPKK6,MEK6,MKK6,PRKMK6,SAPKK-3,SAPKK3
Molecular Weight	The recombinant human MKK6/GST chimera consists of 571 amino acids and has a calculated molecular mass of 65.3 kDa. It migrates as an approximately 60 kDa band in SDS-PAGE under reducing conditions.
predicted N	Met
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human MKK6 isoform 1 (P52564-1) (Met 1-Asp 334) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Bio-activity	Kinase activity untested
Research Area	Signaling |Signal Transduction |Protein Kinase |Intracellular Kinase |MAP2K (Mitogen-Activated Protein Kinase Kinase)
Formulation	Supplied as sterile 20mM Tris, 500mM NaCl, pH 8.0 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6 and MKK6, is a protein which belongs to the?protein kinase superfamily, STE Ser / Thr protein kinase family and MAP kinase kinase subfamily. MAP2K6 / MKK6 contains one?protein kinase domain. Mitogen-activated protein kinases are members of a conserved cascade of kinases involved in many signal transduction pathways. They stimulate phosphorylation of transcription factors in response to extracellular signals such as growth factors, cytokines, ultraviolet light, and stress-inducing agents. MAP2K6 / MKK6 exists in a variety of alternatively spliced isoforms with distinct patterns of tissue expression. Isoform 2 of MAP2K6 / MKK6 is only expressed in skeletal muscle. Isoform 1 of MAP2K6 / MKK6 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas.
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