Human / Mouse / Rat / Rhesus / Canine BMP-2 Protein (Fc Tag)
BDA2,BDA2A,BMP-2,BMP2A
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| Catalog Number | P10426-H01H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | BDA2,BDA2A,BMP-2,BMP2A |
| Molecular Weight | The recombinant human BMP2 consists of 351 amino acids and has a predicted molecular mass of 39.5 kDa. |
| predicted N | Glu 20 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE and SEC-HPLC Analysis. |
| Protein Construction | A DNA sequence encoding the mature form of human BMP2 (NP_001191.1) (Gln 283-Arg 396) was fused with the Fc region of human IgG1 at the C-terminus. The mature form sequences of human, mouse, rat, rhesus and canine BMP2 are identical. |
| Bio-activity | 1.Measured by its ability to bind recombinant human Nog-Fc (P10267-H02H) in a functional ELISA. 2. Measured by its ability to bind recombinant human ALK3-Fch (P10446-H03H) in a functional ELISA. 3. Measured by its ability to bind recombinant mouse ALK3-Fch (P50078-M03H) in a functional ELISA. 4. Measured by its ability to bind recombinant human BMPR-II-Fc (P10551-H03H) in a functional ELISA. |
| Research Area | Immunology |Signal Transduction |Cytoskeleton / ECM |Extracellular Matrix |Structures |Bone | |
| Formulation | Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma. |
| Reference |