Human NDRG1 / CAP43 Protein (His Tag)
NDRG1, CAP43, DRG, RTP
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| Catalog Number | P14119-H08E |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | NDRG1, CAP43, DRG, RTP |
| Molecular Weight | The recombinant human NDRG1 consists of 401 amino acids and predicts a molecular mass of 43.8 KDa. It migrates as an approximately 43 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | > 85 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human NDRG1 (Q92597) (Met1-Cys394) was expressed with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | Cancer |Oncoprotein & suppressor & biomarker |Oncoprotein |Signal transducers |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | NDRG1 gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. NDRG1 is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. NDRG1 is necessary for p53-mediated caspase activation and apoptosis. Mutations in NDRG1 gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. NDRG1 is a stress-responsive protein involved in hormone responses, cell growth, and differentiation. It acts as a tumor suppressor in many cell types. |
| Reference |