Human ORM2 Protein (His Tag)
AGP-B,AGP-B',AGP2,ORM2
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| Catalog Number | P13299-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | AGP-B,AGP-B',AGP2,ORM2 |
| Molecular Weight | The recombinant human ORM2 consists of 194 amino acids and predicts a molecular mass of 23.1 KDa. It migrates as an approximately 23 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | Gln 19 |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human ORM2 (P19652) (Met1-Ser201) was expressed with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | Cardiovascular |Blood |Serum Protein |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | ORM2 belongs to the calycin superfamily, lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids. Lipocalins can be found in gram negative bacteria, vertebrate cells, and invertebrate cells, and in plants. They are associated with many biological processes. ORM2 functions as transport protein in the blood stream. It is expressed by the liver and secreted in plasma. It seems that ORM2 function in modulating the activity of the immune system during the acute-phase reaction. It binds various hydrophobic ligands in the interior of its beta-barrel domain. It also binds synthetic drugs and influences their distribution and availability. |
| Reference |