Human PGRL / IGSF8 Protein (His Tag)

CD316,CD81P3,EWI-2,EWI2,KCT-4,LIR-D1,PGRL

Catalog Number	P13435-H08H
Organism Species	Human
Host	Human Cells
Synonyms	CD316,CD81P3,EWI-2,EWI2,KCT-4,LIR-D1,PGRL
Molecular Weight	The recombinant human IGSF8 consists of 563 amino acids and predicts a molecular mass of 60 KDa. It migrates as an approximately 63 KDa band in SDS-PAGE under reducing conditions.
predicted N	Arg 28
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human IGSF8 (Q969P0-1) (Met1-Thr579) was expressed with a polyhistidine tag at the C-terminus.
Bio-activity
Research Area	Cancer \|Cancer immunology \|Tumor-associated antigen
Formulation	Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Glazar AI, et al. (2009) Immunoglobulin superfamily member IgSF8 (EWI-2) and CD9 in fertilisation: evidence of distinct functions for CD9 and a CD9-associated protein in mammalian sperm-egg interaction. Reprod Fertil Dev. 21(2): 293-303. Murdoch JN, et al. (2003) Genomic organization and embryonic expression of Igsf8, an immunoglobulin superfamily member implicated in development of the nervous system and organ epithelia. Mol Cell Neurosci. 22(1): 62-74. Zhang XA, et al. (2003) EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. Cancer Res. 63 (10): 2665-74.