Human PPC-DC / PPCDC Protein (His Tag)
PPCDC, COAC
- 100ug (NPP2421) Please inquiry
| Catalog Number | P14572-H07E |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | PPCDC, COAC |
| Molecular Weight | The recombinant human PPCDC consists of 219 amino acids and predicts a molecular mass of 24.3 KDa. It migrates as an approximately 24 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | His |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mature form of human PPCDC (AAH14409.1) (Met1-Ser204) was expressed with a polyhistidine tag at the N-terminus. |
| Bio-activity | |
| Research Area | Cancer |Signal transduction |Metabolism |Vitamins / Minerals |
| Formulation | Lyophilized from sterile PBS, 15% Glycerol, pH 8.0. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | PPC-DC, also known as PPCDC, belongs to the HFCD (homo oligomeric flavin containing Cys decarboxylase) superfamily which takes a part in the biosynthesis of coenzyme A (CoA) from pantothenate (Vitamin B). Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. This process include several steps: the phosphorylation of pantothenate, the conversion of 4’-hosphopantothenate to 4''-phosphopantetheine, the adenylation by phosphopantetheine adenylyltransferase to form dephospho-CoA and the phosphorylation by dephospho-CoA kinase to form CoA. PPC-DC, one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine. |
| Reference |