Human PPIL2 Protein (aa 280-457, His Tag)

CYC4,Cyp-60,CYP60,hCyP-60,UBOX7

Catalog Number	P14418-H07E
Organism Species	Human
Host	E. coli
Synonyms	CYC4,Cyp-60,CYP60,hCyP-60,UBOX7
Molecular Weight	The recombinant human PPIL2 consists of 193 amino acids and predicts a molecular mass of 21.9 KDa. It migrates as an approximately 24 KDa band in SDS-PAGE under reducing conditions.
predicted N	His
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the mature form of human PPIL2 (Q13356-2) (Gly280-Pro457) was expressed with a polyhistide tag at the N-terminus.
Bio-activity
Research Area
Formulation	Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	PPIL2, is an enzyme which belongs to the cyclophilin family. The cyclophilins are peptidylprolyl isomerases and are highly conserved ubiquitous. They play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. PPIL2 interacts with the proteinase inhibitor eglin c and is localized in the nucleus. It contains 1 PPIL2 cyclophilin-type domain and 1 U-box domain. PPIL2 accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Reference	Grouse LH. et al., 2003, Proc Natl Acad Sci. 99 (26): 16899-903. Lennon G. et al., 1997, Genome Res. 6 (9): 791-806. Payan DG. et al., 1996, Biochem J. 314 (1): 313-9.