Human PPM1G / PP2C-gamma Protein (aa 317-546, His Tag)
PP2CG,PP2CGAMMA,PPP2CG
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| Catalog Number | P11245-H07E |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | PP2CG,PP2CGAMMA,PPP2CG |
| Molecular Weight | The recombinant human PPM1G comprises 241 amino acids and has a predicted molecular mass of 26.6 kDa. It migrates as an approximately 30 kDa band in SDS-PAGE under reducing conditions. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human PPM1G (O15355) C-terminal fragment (Met 317-Asp 546) was expressed, with a polyhistidine tag at the N-terminus. |
| Bio-activity | |
| Research Area | Cancer |Signal transduction |Protein Phosphorylation |Serine / threonine Phosphatase |
| Formulation | Lyophilized from sterile 50mM Tris, 1mM DTT, 20% glycerol, pH 7.5 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Protein phosphatase 1G, also known as Protein phosphatase 1C, Protein phosphatase 2C isoform gamma, Protein phosphatase magnesium-dependent 1 gamma, PP2C-gamma, PPM1G and PPM1C, is a cytoplasm protein which belongs to the PP2C family. PPM1G / PP2C-gamma is widely expressed. It is most abundant in testis, skeletal muscle, and heart. Alternatively spliced transcript variants encoding the same protein have been described. PP2C family members are known to be negative regulators of cell stress response pathways. PPM1G / PP2C-gamma is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. PPM1G / PP2C-gamma also plays a role in regulating cell cycle progression. |
| Reference |