Human PROS1 / Protein S Protein (His Tag)
PROS,Protein S,PS21,PS22,PS23,PS24,PS25,PSA,THPH5,THPH6
- 100ug (NPP2435) Please inquiry
| Catalog Number | P12179-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | PROS,Protein S,PS21,PS22,PS23,PS24,PS25,PSA,THPH5,THPH6 |
| Molecular Weight | The recombinant human PROS1 consists of 663 amino acids and predicts a molecular mass of 74.1 KDa. It migrates as an approximately 69-89 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | Asn 25 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human PROS1 (P07225) (Met1-Ser676) was expressed with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | Immunology |Innate Immunity |Complement System |Regulatory |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | PROS1, also known as protein S, is a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. PROS1 has two isoforms: a free, functionally active form and an inactive form complexed with C4b-binding protein. Besides its anticoagulant function, PROS1 also acts as an agonist for the tyrosine kinase receptors Tyro3, Axl, and Mer. The endothelium expresses Tyro3, Axl, and Mer and produces protein S. The interaction of protein S with endothelial cells and particularly its effects on angiogenesis have not yet been analyzed. |
| Reference |