Human PTH / PTH1 / Parathyroid Hormone Protein (Fc Tag)
PTH,PTH1
- 100ug (NPP4198) Please inquiry
| Catalog Number | P13192-H01H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | PTH,PTH1 |
| Molecular Weight | The recombinant human PTH/Fc is a disulfide-linked homodimer. The reduced monomer comprises 344 amino acids and has a predicted molecular mass of 37.9 kDa. The apparent molecular mass of the protein is approximately 40 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| predicted N | Glu |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human PTH (P01270) (Ser32-Gln115) was expressed,with the fused Fc region of human IgG1 at the N-terminus. |
| Bio-activity | |
| Research Area | Neuroscience |Neurology process |Circadian Rhythm |Hormones |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide. PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Parathyroid hormone (PTH) has been proved to play a pivotal role in maintaining myocardial contractility as well as effective natriuresis, and possible pathogenic mechanisms contributing to heart failure secondary to hypocalcemia and hypoparathyroidism. With the increased population of preosteoblastic lineages and the osteoblastic activation, Parathyroid hormone (PTH) drives anabolism in bone. Experiments have recently reported that PTH affects bone cells in a dual pathway - mediating osteoblastic (preosteoblastic) activities or osteocytic synthesis of sclerostin. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH), also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. |
| Reference |