Human PTH1R / PTHR1 / PTH1 Receptor Protein (His Tag)
MGC138426, MGC138452, PFE, PTHR, PTHR1
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| Catalog Number | P12232-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | MGC138426, MGC138452, PFE, PTHR, PTHR1 |
| Molecular Weight | The recombinant human PTH1R consists of 173 amino acids and has a predicted molecular mass of 20 kDa. As a result of glycosylation, the apparent molecular mass of rh PTH1R is approximately 30-40 kDa in SDS-PAGE under reducing conditions. |
| predicted N | Asp 27 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human PTH1R (Q03431) extracellular domain (Met 1-Gly 188) was fused with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | Neuroscience |Neurotransmitter |Neuropeptides |Hormones |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane protein which belongs to the G-protein coupled receptor 2 family. PTH1R is expressed in most tissues. It is most abundant in kidney, bone and liver. PTH1R is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C. In bone, PTH1R is expressed on the surface of osteoblasts. When the receptor is activated, these cells in turn stimulate osteoclasts to ultimately increase the resorption rate. PTH1R is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of PTH1R is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in PTH1R are the cause of Jansen metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), enchondromatosis multiple (ENCHOM), Eiken skeletal dysplasia (EISD) and primary failure of tooth eruption (PFE). |
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