Human Profilin 2 / PFN2 Protein (His Tag)
D3S1319E,PFL
- 100ug (NPP2434) Please inquiry
| Catalog Number | P14496-H07E |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | D3S1319E,PFL |
| Molecular Weight | The recombinant human PFN2 consists of 155 amino acids and predicts a molecular mass of 16.9 KDa. It migrates as an approximately 16 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | His |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human PFN2 (AAH18049.1) (Met1-Phe140) was expressed with a polyhistidine tag at the N-terminus. |
| Bio-activity | |
| Research Area | Neuroscience |Cell Adhesion Proteins |Cytoskeletal Proteins |Microfilaments |Actin etc |Actin Assembly | |
| Formulation | Lyophilized from sterile 50mM Tris, 10% Glycerol, pH 8.0. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Profilin 2, also known as PFN2, is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver. Profilin 2 binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. Profilin 2 is thought to regulate actin polymerization in response to extracellular signals. It inhibits the formation of IP3 and DG by binding to PIP2. |
| Reference |