Human RASI-1 / MMP19 Protein
MMP18,RASI-1
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| Catalog Number | P13912-HNAE |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | MMP18,RASI-1 |
| Molecular Weight | The recombinant human MMP19 consists of 157 amino acids and predicts a molecular mass of 17.6 KDa. It migrates as an approximately 18 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | > 85 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the catalytic domain of human MMP19 (Q99542-1) (Leu101-Gly256) was expressed, with a N-terminal Met. |
| Bio-activity | |
| Research Area | Cancer |Invasion microenvironment |Adhesion molecule |Extracelluar matrix |Extracellualr matrix proteases & regulators |Matrix metalloproteinase (MMP) | |
| Formulation | Lyophilized from sterile 20mM Tris, 100mM NaCl, 0.5M Arg, 5mM CaCl2, 0.03% Brij35, 50uM ZnCl2, 1/0.1mM GSH/GSSG, pH 8.0 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | MMP19, also known as RASI-1, is a member of the peptidase M10A family. It contains 4 hemopexin-like domains and is expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. It is a matrix metalloproteinase (MMP). Proteins of the MMP family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP19 may play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients. |
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