Human RCAS1 / EBAG9 Protein (His Tag)
EB9,PDAF
- 100ug (NPP1585) Please inquiry
| Catalog Number | P14012-H07E |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | EB9,PDAF |
| Molecular Weight | The recombinant human EBAG9 consists of 201 amino acids and predicts a molecular mass of 23 KDa. It migrates as an approximately 33 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | His |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mature form of human EBAG9 (O00559) (Arg28-Ser213) was expressed with a polyhistidine tag at the N-terminus. |
| Bio-activity | |
| Research Area | Developmental Biology |Reproduction |Hormones |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | RCAS1, also known as EBAG9, is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. RCAS1 gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor which binds to the estrogen-responsive element (ERE) found in the 5'-flanking region of RCAS1 gene. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for RCAS1 gene. EBAG9 may participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. |
| Reference |