Human RNASET2 Protein (His Tag)
bA514O12.3,RNASE6PL,RP11-514O12.3
- 100ug (NPP2467) Please inquiry
| Catalog Number | P13509-H08B |
|---|---|
| Organism Species | Human |
| Host | Baculovirus-Insect Cells |
| Synonyms | bA514O12.3,RNASE6PL,RP11-514O12.3 |
| Molecular Weight | The secreted recombinant human RNASET2 comprises 242 amino acids and has a predicted molecular mass of 28.5 kDa. The apparent molecular mass of rh RNASET2 is approximately 35 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| predicted N | Asp 25 |
| SDS-PAGE |  |
| Purity | > 98 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human RNASET2 isoform 1 (O00584-1) (Met 1-His 256) was fused with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | Epigenetics |DNA / RNA |RNA Processing |Other in RNA processing |
| Formulation | Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | RNASET2 (ribonuclease T2) is an enzyme which belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications. |
| Reference |