Human RRM1 Protein (His & GST Tag)
R1,RIR1,RR1
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| Catalog Number | P14316-H20B |
|---|---|
| Organism Species | Human |
| Host | Baculovirus-Insect Cells |
| Synonyms | R1,RIR1,RR1 |
| Molecular Weight | The recombinant human RRM1/GST chimera consists of 1029 amino acids and has a calculated molecular mass of 117.9 kDa. The recombinant protein migrates approximately 98 kDa band in SDS-PAGE under reducing conditions. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human RRM1 (P23921) (Met1-Ser792) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
| Bio-activity | |
| Research Area | Epigenetics |DNA / RNA |DNA Synthesis |Other in DNA synthesis |
| Formulation | Lyophilized from sterile 20mM Tris, 500mM Nacl, pH 8. 0, 3mM DTT, 10% glycerol 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | RRM1 is a subunit of ribonucleoside-diphosphate reductase which is constituted by two subunits. Ribonucleoside-diphosphate reductase is an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. RRM1 is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. RRM1 may play a role in malignancies and disease that involve this region. |
| Reference |