Human S100A7 / PSOR1 Protein
PSOR1,S100A7c
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| Catalog Number | P11141-HNAE |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | PSOR1,S100A7c |
| Molecular Weight | The recombinant human S100A7 consisting of 101 amino acids and migrates as an 11.6 kDa band in SDS-PAGE under reducing conditions as predicted. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | > 98 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the native human S100A7 (NP_002954.2) (Met 1-Gln 101) was expressed. |
| Bio-activity | |
| Research Area | Cardiovascular |Atherosclerosis |Vascular Inflammation |Inflammatory mediators |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Protein S100-A7, also known as S100 calcium-binding protein A7, Psoriasin, S100A7, and PSOR1, is a secreted protein which belongs to the S-100 family. S100A7 was first isolated from skin involved by psoriasis, which can be induced in cultured squamous epithelial cells. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesting an association with abnormal pathways of differentiation. S100A7 plays a role in the pathogenesis of inflammatory skin disease, as a chemotactic factor for hematopoietic cells. It also plays a role in early stages of breast tumor progression in association with the development of the invasive phenotype. |
| Reference |