Human STAT4 Protein (His Tag)

SLEB11

Catalog Number	P13189-H07B
Organism Species	Human
Host	Baculovirus-Insect Cells
Synonyms	SLEB11
Molecular Weight	The recombinant human STAT4 consists of 767 amino acids and predicts a molecular mass of 88 kDa. It migrates as an approximately 70 kDa band in SDS-PAGE under reducing conditions.
predicted N	Met
SDS-PAGE
Purity	> 85 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human STAT4 (Q14765) (Met 1-Glu 748) was expressed, with a polyhistidine tag at the N-terminus.
Bio-activity
Research Area	Epigenetics \|Transcription \|Other factors
Formulation	Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 20% gly, 0.5mM DTT 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Thierfelder WE, et al. (1996) Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature. 382(6587):171-4. Hye-Soon L, et al. (2007) Association of STAT4 with Rheumatoid Arthritis in the Korean Population. Mol Med. 13(9-10): 455-60. Chitnis T, et al. (2001) Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest. 108(5): 739-47.