Human STC2 / Stanniocalcin 2 Protein (Fc Tag)
STC-2,STCRP
- 100ug (NPP2516) Please inquiry
| Catalog Number | P13653-H02H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | STC-2,STCRP |
| Molecular Weight | The recombinant human STC2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 519 amino acids and has a predicted molecular mass of 57.7 kDa. The apparent molecular mass of the protein is approximately 63 kDa in SDS-PAGE under reducing conditions. |
| predicted N | Thr 25 |
| SDS-PAGE |  |
| Purity | > 85 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human STC2 (O76061) (Met1-Arg302) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Cancer |Signal transduction |Signaling Pathway |Calcium Signaling |Others in Calcium Signaling |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | STC2 is a secreted, homodimeric glycoprotein which expressed in a wide variety of tissues. STC2 has an anti-hypocalcemic action on calcium and phosphate homeostasis. It may have autocrine or paracrine functions. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. STC2 has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. It may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. |
| Reference |