Human STC2 / Stanniocalcin 2 Protein (His Tag)
STC-2,STCRP
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| Catalog Number | P13653-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | STC-2,STCRP |
| Molecular Weight | The recombinant human STC2 comprises 289 amino acids and has a predicted molecular mass of 32.1 kDa. The apparent molecular mass of the protein is approximately 35-42 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| predicted N | Thr 25 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human STC2 (O76061) (Met1-Arg302) was expressed with a C-terminal polyhistidine tag. |
| Bio-activity | |
| Research Area | Cancer |Signal transduction |Signaling Pathway |Calcium Signaling |Others in Calcium Signaling |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | STC2 is a secreted, homodimeric glycoprotein which expressed in a wide variety of tissues. STC2 has an anti-hypocalcemic action on calcium and phosphate homeostasis. It may have autocrine or paracrine functions. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. STC2 has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. It may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. |
| Reference |