Human Sclerostin / SOST Protein (His Tag)
CDD,SOST1,VBCH
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| Catalog Number | P10593-H07H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | CDD,SOST1,VBCH |
| Molecular Weight | The recombinant human SOST is a monomeric protein consisting of 197 amino acids and predicts a molecular mass of 22.5 kDa. As a result of glycosylation, the apparent molecular mass of rhSOST is approximately 28 kDa in SDS-PAGE under reducing conditions.. |
| predicted N | N-His |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mature form of human SOST (NP_079513.1) (Gln 24-Tyr 213) was fused with a polyhistidine tag at the N-terminus. |
| Bio-activity | |
| Research Area | Immunology |Signal Transduction |Cellular Senescence and Pathways in Aging |Wnt Family |Wnt Inhibitors |
| Formulation | Lyophilized from sterile PBS, pH 7.2 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteeoblasts differentiated for 21 days, and was originally identified as an important regulator of bone remodeling, homeostasis, and links bone resorption and bone apposition. Recent studies have revealed that Sclerostin protein inhibits the bone growth probably by binding to the extracellular domain of the Wnt coreceptors LRP5 and LRP6 and disrupting Wnt-induced Frizzled-LRP complex formation. |
| Reference |