Human TETHERIN / BST2 / CD317 Protein (Fc Tag)

CD317,TETHERIN

Catalog Number	P13370-H01H
Organism Species	Human
Host	Human Cells
Synonyms	CD317,TETHERIN
Molecular Weight	The recombinant human BST2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 372 amino acids and has a predicted molecular mass of 41 kDa. The apparent molecular mass of the protein is approximately 51 kDa in SDS-PAGE under reducing conditions due to glycosylation.
predicted N	Glu
SDS-PAGE
Purity	> 90 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human BST2 (Q10589) (Asn49-Ser160) was expressed,with the fused Fc region of human IgG1 at the N-terminus.
Bio-activity
Research Area	Cardiovascular \|Blood \|Other in Blood
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Ishikawa J, et al. (1995) Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. Genomics. 26 (3): 527-34. Viswanathan K, et al. (2011) BST2/Tetherin enhances entry of human cytomegalovirus. PLoS Pathog. 7(11):e1002332. Gifford RJ. (2011) No trespassing: ancient BST2 deletion confers protection against simian immunodeficiency virus infection of humans. Hum Mutat. 32(11).