Human TL1A / TNFSF15 Protein (Fc Tag)
TL1,TL1A,VEGI,VEGI192A
- 100ug (NPP2250) Please inquiry
| Catalog Number | P17049-H01H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | TL1,TL1A,VEGI,VEGI192A |
| Molecular Weight | The recombinant human TNFSF15 consists of 440 amino acids and predicts a molecular mass of 48.9 kDa. |
| predicted N | Glu |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE. |
| Protein Construction | A DNA sequence encoding the human TNFSF15 (NP_005109.2) (Leu72-Leu251) was expressed with the Fc region of human IgG1 at the N-terminus. |
| Bio-activity | |
| Research Area | Immunology |Signal Transduction |Growth Factor & Receptor |Tumor Necrosis Factor (TNF) & Receptor |Tumor Necrosis Factor (TNF) |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It mediates activation of NF-kappa-B. It also inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis. It is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. |
| Reference |