Human TMED4 / ERS25 Protein (His Tag)

ERS25,GMP25iso,HNLF,p24alpha3

Catalog Number	P13729-H08H
Organism Species	Human
Host	Human Cells
Synonyms	ERS25,GMP25iso,HNLF,p24alpha3
Molecular Weight	The recombinant human TMED4 consists of 176 amino acids and predicts a molecular mass of 20.7 KDa. It migrates as an approximately 23 KDa band in SDS-PAGE under reducing conditions.
predicted N	Leu 30
SDS-PAGE
Purity	> 85 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human TMED4 (Q7Z7H5-1) (Met1-Arg194) was expressed with a polyhistidine tag at the C-terminus.
Bio-activity
Research Area	Immunology \|Signal Transduction \|Metabolism \|Pathways and Processes \|Metabolism processes \|Apoptosis \|
Formulation	Lyophilized from sterile PBS, 10% Glycerol, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	TMED4, also known as ERS25, belongs to the EMP24/GP25L family. TMED4 may play a role in the regulation of heat-shock response and apoptosis. It is involved in vesicular protein trafficking, mainly in the early secretory pathway. TMED4 may also play a role in the biosynthesis of secreted cargo including processing. It functions in the regulation of heat-shock response and apoptosis. TMED4 also is involved in endoplasmic reticulum stress response.
Reference	Hartley JL. et al., 2001, Genome Res. 10 (11): 1788-95. Matoba R. et al., 1994, Gene. 146 (2): 199-207. Matsuda A. et al., 2003, Oncogene. 22 (21): 3307-18.