Human TMEM25 Protein (His Tag)
TMEM25
- 100ug (NPP2545) Please inquiry
Catalog Number | P13750-H08H |
---|---|
Organism Species | Human |
Host | Human Cells |
Synonyms | TMEM25 |
Molecular Weight | The recombinant human TMEM25 consists of 209 amino acids and predicts a molecular mass of 22.8 KDa. It migrates as an approximately 43 KDa band in SDS-PAGE under reducing conditions. |
predicted N | Glu 27 |
SDS-PAGE | |
Purity | > 95 % as determined by SDS-PAGE |
Protein Construction | A DNA sequence encoding the human TMEM25 (AAH51841.1) (Met1-Pro224) was expressed with a polyhistidine tag at the C-terminus. |
Bio-activity | |
Research Area | |
Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
Background | TMEM25 is a novel member of the immunoglobulin superfamily. Immunoglobulin superfamily members are implicated in immune responses, growth factor signaling, and cell adhesion. TMEM25 contains 1 Ig-like (immunoglobulin-like) domain and is a target of pharmacogenomics in the field of oncology and regenerative medicine. TMEM25 isoform 1, consisting of exons 1-9, encoded a 366-aa transmembrane protein. TMEM25 isoform 2, consisting of exons 1-4 and 6-9, encoded a 322-aa secreted protein. TMEM25 mRNA was expressed in brain, including cerebellar cortex and hippocampus, as well as in neuroblastoma, brain tumors, and gastric cancer. Human TMEM25 gene was located at the 11q23.3 oncogenomic recombination hotspot around the MLL amplicon and the neuroblastoma deleted region. |
Reference |