Human TSC22D1 Protein (His Tag)
Ptg-2,TGFB1I4,TSC22
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| Catalog Number | P12724-H07E |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | Ptg-2,TGFB1I4,TSC22 |
| Molecular Weight | The recombinant human TSC22D1 consisting of 155 amino acids and has a calculated molecular mass of 17.2 kDa. It migrates as an 20 kDa band in SDS-PAGE under reducing conditions as predicted. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | > 92 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human TSC22D1 isoform 2 (Q15714-2) (Met 1-Ala 144) was expressed, with a polyhistidine tag at the N-terminus. |
| Bio-activity | |
| Research Area | Epigenetics |Transcription |Transcription Factor & Regulator |Basic Leucine Zipper (bZIP) Transcription Factors |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | TSC22 domain family, member 1 (TSC22D1) is one of the TGF-beta-stimulated clone-22 (TSC-22). TSC-22 was reported to be a differentiation-inducing factor which negatively regulates the growth of salivary gland cancer cells. TSC22D1, which encodes transforming growth factor beta-stimulated clone 22 (TSC-22), is thought to be a tumor suppressor because its expression is lost in many glioblastoma, salivary gland, and prostate cancers. TSC-22 is the founding member of the TSC-22/DIP/Bun family of leucine zipper transcription factors. TSC-22 may play an important role in maintaining the differentiated phenotype in salivary gland tumors, and may be a possible target of leukemia therapy. TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity. |
| Reference |