Human Tubulin folding cofactor A / TBCA Protein
TBCA
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| Catalog Number | P13918-HNAE |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | TBCA |
| Molecular Weight | The recombinant human TBCA consists of 109 amino acids and predicts a molecular mass of 13 KDa. It migrates as an approximately 16 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mature form of human TBCA (O75347) (Met1-Ala108) was expressed, with a N-terminal Met. |
| Bio-activity | |
| Research Area | Signaling |Signal Transduction |Cytoskeleton / ECM |Cytoskeletal Proteins |Microtubules |Tubulin | |
| Formulation | Lyophilized from sterile PBS, pH 7.5 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Tubulin folding cofactor A belongs to the TBCA family. It is one of four proteins (cofactors A, D, E, and C) involved in the early step of the tubulin folding pathway. These proteins can fold intermediates and finally lead to correctly folded beta-tubulin. It is believed that tubulin folding cofactors A and D play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Tubulin folding cofactor E binds to the cofactor D/beta-tubulin complex; interaction with tubulin folding cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. |
| Reference |