Human ULBP2 / N2DL-2 Protein (Fc Tag)
ALCAN-alpha,N2DL2,NKG2DL2,RAET1H,UNQ463 / PRO791
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| Catalog Number | P12143-H02H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | ALCAN-alpha,N2DL2,NKG2DL2,RAET1H,UNQ463 / PRO791 |
| Molecular Weight | The recombinant human ULBP2/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 433 amino acids and has a predicted molecular mass of 48.7 kDa. As a result of glycosylation, the apparent molecular mass of rhULBP2/Fc monomer is approximately 58 kDa in SDS-PAGE under reducing conditions. |
| predicted N | Gly 26 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human ULBP2 (Q9BZM5) (Met 1-Ser 217),without the pro peptide, w was fused with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Immunology |Innate Immunity |Natural Killer Cell (NK Cell) |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein which belongs to the MHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. |
| Reference |