Human VAMP3 / Cellubrevin Protein (His Tag)
VAMP3, SYB3
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| Catalog Number | P14481-H07E |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | VAMP3, SYB3 |
| Molecular Weight | The recombinant human VAMP3 consists of 92 amino acids and predicts a molecular mass of 10.6 KDa. It migrates as an approximately 11 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | His |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human VAMP3 (Q15836) (Met1-Lys77) was expressed with a polyhistidine tag at the N-terminus. |
| Bio-activity | |
| Research Area | Cancer |Signal transduction |Protein Trafficking |Vesicle Transport |SNAPs & SNAREs |
| Formulation | Lyophilized from sterile PBS, 10% Glycerol, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | VAMP3, also known as cellubrevin, is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. Because of VAMP3 gene's high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, VAMP3 was shown to be the human equivalent of the rodent cellubrevin. In platelets VAMP3 resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. |
| Reference |