Influenza B (B/Florida/4/2006) Hemagglutinin Protein (HA2 Subunit) (Fc Tag)

HA2

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Catalog Number	P11053-V04H2
Organism Species	Influenza B
Host	Human Cells
Synonyms	HA2
Molecular Weight	The recombinant Influenza B virus (B/Florida/4/2006) HA2/mFc is a disulfide-linked homodimeric protein. The reduced monomer comprises 430 amino acids with the predicted molecular mass of 47.6 kDa. As a result of glycosylation, it migrates as an approximately 60 kDa band in SDS-PAGE under reducing conditions.
predicted N	Asp
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the C-terminal fragment (Gly 362-Ala 555) of influenza B virus (B/Florida/4/2006) (ACA33493.1) hemagglutinin, termed as HA2, was fused with the Fc region of mouse IgG1 at the N-terminus.
Bio-activity
Research Area	Microbiology |Pathogenic microorganism |viruses |animal virus |viral illness |Viral tract respiratory illness |
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	White JM, Hoffman LR, Arevalo JH, et al. (1997). "Attachment and entry of influenza virus into host cells. Pivotal roles of hemagglutinin". In Chiu W, Burnett RM, Garcea RL. Structural Biology of Viruses. Suzuki Y (March 2005). "Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses". Biol. Pharm. Bull. 28 (3): 399–408. Senne DA, Panigrahy B, Kawaoka Y, et al. (1996). "Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential". Avian Dis. 40 (2): 425–37