Mouse CD23 / FCER2 Protein (His Tag)
Fcer2a, CD23, Fce2, Fcer2, Ly-42
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| Catalog Number | P50695-M07H |
|---|---|
| Organism Species | Mouse |
| Host | Human Cells |
| Synonyms | Fcer2a, CD23, Fce2, Fcer2, Ly-42 |
| Molecular Weight | The recombinant mouse FCER2A comprises 301 amino acids and predicts a molecular mass of 34.3 kDa. As a result of glycosylation, the apparent molecular mass of mouse FCER2A is approximately 40-45 kDa in SDS-PAGE under reducing conditions. |
| predicted N | His |
| SDS-PAGE |  |
| Purity | > 92 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the extracellular domain of mouse FCER2A isoform A (P20693-1) (Glu 51-Pro 331) was fused with a polyhistidine tag at the N-terminus. |
| Bio-activity | |
| Research Area | Immunology |Cluster of Differentiation (CD) |Granulocyte CD Antigen |CD Antigen (Eosinophils) |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Fc fragment of IgE, low affinity II, receptor for (CD23) or CD23 antigen is a member of the cluster of differentiation family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD23/FCER2 is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Increased levels of soluble CD23/FCER2 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. IgE, in turn, is known to upregulate the cellular expression of CD23 and Fc epsilon RI (high-affinity IgE receptor). |
| Reference |