Call Now

Mouse CD7 Protein (His Tag)

RP23-400P17.1

Catalog Number P50393-M08H
Organism Species Mouse
Host Human Cells
Synonyms RP23-400P17.1
Molecular Weight The secreted recombinant mouse CD7 comprises 138 amino acids and has a predicted molecular mass of 15.7 kDa. As a result of glycosylation, the apparent molecular mass of rmCD7 is approximately 20-30 kDa in SDS-PAGE under reducing conditions.
predicted N Gln 24
SDS-PAGE
Purity > 94 % as determined by SDS-PAGE
Protein Construction A DNA sequence encoding the mouse CD7 (NP_033984.1) extracellular domain (Met 1-Pro 150) was fused with a polyhistidine tag at the C-terminus.
Bio-activity Measured by its ability to bind biotinylated recombinant human SECTM1 in a functional ELISA.
Research Area Immunology |Signal Transduction |Transcription Factors and Regulators |Immunoglobulin-Like Domain Transcription Factors
Formulation Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD7 is a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell / B-cell interaction during early lymphoid development.
Reference
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.