Mouse CES2 / Carboxylesterase-2 Protein (His Tag)
ces2A3
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| Catalog Number | P50515-M08H |
|---|---|
| Organism Species | Mouse |
| Host | Human Cells |
| Synonyms | ces2A3 |
| Molecular Weight | The recombinant mouse CES2 consists of 542 amino acids and has a predicted molecular mass of 60.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmCES2 is approximately 52 kDa. |
| predicted N | Gln 27 |
| SDS-PAGE |  |
| Purity | > 85 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the extracellular domain of mouse CES2 (NP_663578.1) (Met 1-Lys 557) was expressed, with a polyhistidine tag at the C-terminus. |
| Bio-activity | Measured by its ability to hydrolyze pnitrophenylacetate. The specific activity is >90,000 pmoles/min/μg. |
| Research Area | Signaling |Signal Transduction |Metabolism |Lipid metabolism |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin. It also serves to hydrolyze long-chain fatty acid esters and thioesters. It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation. Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors. |
| Reference |