Mouse CHODL / Chondrolectin Protein (Fc Tag)

3110074E07Rik, MT75, PRED12

Catalog Number	P50699-M02H
Organism Species	Mouse
Host	Human Cells
Synonyms	3110074E07Rik, MT75, PRED12
Molecular Weight	The secreted recombinant mouse CHODL/Fc is a disulfide-linked homodimer. The reduced monomer comprises 436 amino acids and has a calculated molecular mass of 48.9 kDa. As a result of glycosylation, the apparent molecular mass of rmCHODL/Fc monomer is approximately 60 kDa in SDS-PAGE under reducing conditions.
predicted N	Arg 22
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the extracellular domain of mouse CHODL (EDK98299.1) (Met 1-Asn 216) was fused with the Fc region of human IgG1 at the C-terminus.
Bio-activity
Research Area	Cancer \|Signal transduction \|Cytoskeleton / ECM \|Cell Adhesion \|Lectin \|C-tyep lectin \|
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Weng L, et al. (2003) A novel alternative spliced chondrolectin isoform lacking the transmembrane domain is expressed during T cell maturation. J Biol Chem. 278(21): 19164-70. Masuda K, et al. (2011) Chondrolectin is a novel diagnostic biomarker and a therapeutic target for lung cancer. Clin Cancer Res. 17(24): 7712-22. Weng L, et al. (2002) Molecular cloning and characterization of human chondrolectin, a novel type I transmembrane protein homologous to C-type lectins. Genomics. 80(1): 62-70.