Mouse CLEC3B / Tetranectin Protein (His Tag)
Tna
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Catalog Number | P50700-M08H |
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Organism Species | Mouse |
Host | Human Cells |
Synonyms | Tna |
Molecular Weight | The recombinant mouse CLEC3B consists of 188 amino acids and predicts a molecular mass of 20.7 KDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmCLEC3B is approximately 25 KDa. |
predicted N | Gln 22 |
SDS-PAGE | |
Purity | > 95 % as determined by SDS-PAGE |
Protein Construction | A DNA sequence encoding the mouse CLEC3B (P43025) (Met 1-Val 202) was expressed, with a C-terminal polyhistidinetag. |
Bio-activity | |
Research Area | Cancer |Invasion microenvironment |Angiogenesis |Adhesion Molecules in Angiogenesis |Extracellular Matrix |Structures | |
Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
Background | Tetranectin (TN), also known as C-type lectin domain family 3, member B (CLEC3B) is a member of the C-type lectin Family. It is plasminogen kringle 4 binding protein and regulates fibrinolysis and proteolytic processes via binding to plasminogen. Tetranectin has been suggested to play a role in tissue remodeling, due to its ability to stimulate plasminogen activation and its expression in developing tissues such as developing bone and muscle. Tetranectin enhances plasminogen activation by a tissue-type plasminogen activator so that it has been suggested to play a role in tissue remodeling. Tetranectin may play a role in the wound healing process. Tetranectin may play a role in neurological diseases and may serve as a diagnostic aid in multiple sclerosis (MS). Tetranectin was found significantly under-expressed in both serum and saliva of metastatic oral squamous cell carcinoma (OSCC) compared to primary OSCC. Tetranectin is thought to enhance proteolytic processes enabling tumor cells to invade and metastasize. |
Reference |