Mouse CSRP1 / CSRP / CRP1 Protein (His Tag)
AA408841,AA959891,AW545626,CRP1,Csrp
- 100ug (NPP3282) Please inquiry
| Catalog Number | P50532-M08E |
|---|---|
| Organism Species | Mouse |
| Host | E. coli |
| Synonyms | AA408841,AA959891,AW545626,CRP1,Csrp |
| Molecular Weight | The recombinant mouse CSRP1 consisting of 203 amino acids and has a calculated molecular mass of 22 kDa. rm CSRP1 migrates as an approximately 23 kDa band in SDS-PAGE under reducing conditions. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mouse CSRP1 (P97315) (Met 1-Glu 193) was expressed, with a polyhistide tag at the C-terminus. |
| Bio-activity | |
| Research Area | Developmental Biology |Metabolism |Pathways and Processes |Metabolism processes |Apoptosis |Nuclear | |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Mouse Cysteine and glycine-rich protein 1, also known as Cysteine-rich protein 1, CSRP1 and CSRP, is a member of the CSRP family which may be involved in regulatory processes important for development and cellular differentiation. CSRP1 contains two LIM zinc-binding domains. The LIM / double zinc-finger motif found in CSRP1 is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Zebrafish CSRP1 is expressed in the mesendoderm and its derivatives. CSRP1 interacts with Dishevelled 2 (Dvl2) and Diversin (Div), which control cell morphology and other dynamic cell behaviors via the noncanonical Wnt and JNK pathways. When CSRP1 message is knocked down, abnormal convergent extension cell movement is induced, resulting in severe deformities in midline structures. In addition, cardiac bifida is induced as a consequence of defects in cardiac mesoderm cell migration. CSRP1 acts as a key molecule of the noncanonical Wnt pathway, which orchestrates cell behaviors during dynamic morphogenetic movements of tissues and organs. |
| Reference |