Mouse Carbonic Anhydrase X / Car10 Protein (His Tag)
Car10, RP23-448I9.1, 2700029L05Rik, BB085816, Ca10
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| Catalog Number | P50768-M08H |
|---|---|
| Organism Species | Mouse |
| Host | Human Cells |
| Synonyms | Car10, RP23-448I9.1, 2700029L05Rik, BB085816, Ca10 |
| Molecular Weight | The secreted recombinant mouse Car10 comprises 289 amino acids and has a calculated molecular mass of 33.1 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 38 kDa band in SDS-PAGE under reducing conditions. |
| predicted N | Gln 23 |
| SDS-PAGE |  |
| Purity | > 97 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mouse Car10 (P61215) (Met 1-Asn 300) was expressed, fused with a C-terminal polyhistidine tag. |
| Bio-activity | Measured by its esterase activity. The specific activity is >10 pmoles/min/μg. |
| Research Area | Cardiovascular |Cardiovascular disease Therapeutic Targets |Hypertension Therapeutic Targets |
| Formulation | Lyophilized from sterile 25mM Tris, 150mM NaCl, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Carbonic anhydrase X, also called carbonic anhydrase - related protein X (CARPX) and CA10, belongs to the CA family of zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide in various biological processes such as respiration, renal tubular acidification and bone resorption. The secreted protein CARPX without CA activity (hydration of CO2) is identified as an acatalytic member of the alpha-carbonic anhydrase subgroup. CARP X expression is detected in the adult total brain and almost all parts of the central nervous system, but not in the fetal brain. Accordingly, CARP X is suggested to play a role in the development of central nervous system, especially the brain. The same CARP X protein are encoded by multiple transcript variants of this gene. |
| Reference |