Mouse Cd52 / CDw52 Protein (Fc Tag)
AI463198,B7,B7-Ag,CAMPATH-1,CLS1,MB7
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| Catalog Number | P50721-M02H |
|---|---|
| Organism Species | Mouse |
| Host | Human Cells |
| Synonyms | AI463198,B7,B7-Ag,CAMPATH-1,CLS1,MB7 |
| Molecular Weight | The recombinant mouse Cd52 consists 261 amino acids and predicts a molecular mass of 29 kDa. |
| predicted N | Gly 24 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE. |
| Protein Construction | A DNA sequence encoding the mouse Cd52 (NP_038734.1) (Met1-Lys46) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | CD52 / CDW52 is a small glycosylphosphatidylinositol (GPI) anchored glycoprotein. It has a mature peptide comprising only 12 amino acids and is abundantly expressed on human lymphocytes. From the clinical point of view this protein is an important target for therapeutic interventions aimed at leukocyte depletion in hematological malignancies and post-transplant immunosuppression. CD52 / CDW52 may play a role in carrying and orienting carbohydrate. It is an unusually good target for complement-mediated cell lysis. |
| Reference |