Mouse DKK-1 Protein (His Tag)
mdkk-1
- 100ug (NPP2760) Please inquiry
| Catalog Number | P57248-M08H |
|---|---|
| Organism Species | Mouse |
| Host | Human Cells |
| Synonyms | mdkk-1 |
| Molecular Weight | The recombinant mouse DKK1 consists of 252 amino acids and predicts a molecular mass of 27.6 kDa. |
| predicted N | Thr 32 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE. |
| Protein Construction | A DNA sequence encoding the mouse DKK1 (NP_034181.2) (Met1-His272) was expressed with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | Cardiovascular |Blood |Other in Blood |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers. |
| Reference |