Mouse EphA3 Protein (His Tag)
AW492086,Cek4,End3,ETK1,Hek,Hek4,Mek4,Tyro4
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| Catalog Number | P51122-M08H |
|---|---|
| Organism Species | Mouse |
| Host | Human Cells |
| Synonyms | AW492086,Cek4,End3,ETK1,Hek,Hek4,Mek4,Tyro4 |
| Molecular Weight | The recombinant mouse EPHA3 comprises 532 amino acids and has a predicted molecular mass of 60.2 kDa. |
| predicted N | Glu 21 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mouse EPHA3 (NP_034270.1) (Met1-His541) was expressed with a C-terminal polyhistidine tag. |
| Bio-activity | 1. Measured by its binding ability in a functional ELISA. 2. Immobilized mouse EPHA3-His at 10 μg/mL (100 μL/well) can bind mouse EFNA5-Fc (P50597-M02H). The EC50 of mouse EFNA5-Fc (P50597-M02H) is 4.9-11.4ng/mL. |
| Research Area | Cancer |Invasion microenvironment |Angiogenesis |Eph Receptors |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | EPHA3 gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EPHA3 gene encodes a protein that binds ephrin-A ligands. EPHA3 is involved in the retinotectal mapping of neurons. It may also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. |
| Reference |