Mouse EphA3 Protein (aa 569-984, His & GST Tag)
AW492086,Cek4,End3,ETK1,Hek,Hek4,Mek4,Tyro4
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| Catalog Number | P51122-M20B |
|---|---|
| Organism Species | Mouse |
| Host | Baculovirus-Insect Cells |
| Synonyms | AW492086,Cek4,End3,ETK1,Hek,Hek4,Mek4,Tyro4 |
| Molecular Weight | The recombinant mouse EPHA3/GST chimera consists of 653 amino acids and has a calculated molecular mass of 74.3 kDa. The recombinant protein migrates as an approximately 66 kDa band in SDS-PAGE under reducing conditions. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mouse EPHA3 (EDK98238.1) (Gly569-Val984) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
| Bio-activity | Kinase activity untested |
| Research Area | Cancer |Invasion microenvironment |Angiogenesis |Eph Receptors |
| Formulation | Supplied as sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 8.0. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | EPHA3 gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EPHA3 gene encodes a protein that binds ephrin-A ligands. EPHA3 is involved in the retinotectal mapping of neurons. It may also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. |
| Reference |