Mouse IGFBP7 / IBP-7 Protein (Fc Tag)
AGM,Fstl2,Mac25
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| Catalog Number | P51125-M02H |
|---|---|
| Organism Species | Mouse |
| Host | Human Cells |
| Synonyms | AGM,Fstl2,Mac25 |
| Molecular Weight | The recombinant mouse Igfbp7 consists 497 amino acids and predicts a molecular mass of 53.3 kDa. |
| predicted N | Ser 26 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE. |
| Protein Construction | A DNA sequence encoding the mouse Igfbp7 (AAH92538.1) (Met1-Leu281) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Cancer |Invasion microenvironment |Angiogenesis |Growth Factor & Receptor |Insulin-like Growth Factor (IGF) System |IGF Binding Protein & Regulator | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Insulin like growth factor binding protein 7 (IGFBP7) is a member of the IGFBP family. It has been identified in colorectal adenocarcinoma (CRC) cell lines. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are clearly distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF, or act in an IGF-independent manner in the prostate. IGFBP7 could inhibit cell growth, decrease soft agar colony formation activity and induce apoptosis in RKO and SW620 cells. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity. |
| Reference |