Mouse IL-13Ra1 Protein (His & Fc Tag)
AI882074,CD213a1,IL-13r[a],Il13ra,NR4
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| Catalog Number | P50088-M03H |
|---|---|
| Organism Species | Mouse |
| Host | Human Cells |
| Synonyms | AI882074,CD213a1,IL-13r[a],Il13ra,NR4 |
| Molecular Weight | The recombinant mouse IL13Rα1/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 563 amino acids and has a predicted molecular mass of 64 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm IL13Rα1/Fc monomer is approximately 80-90 kDa due to glycosylation. |
| predicted N | Ala 26 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the extracellular domain (Met 1-Thr 340) of mouse IL13Rα1 (NP_598751.3) precursor was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus. |
| Bio-activity | Immobilized mouse IL13 (P50225-MNAH) at 10 μg/ml (100 μl/well) can bind mouse IL13RA1-Fch with a linear range of 0.06-0.5 μg/ml. |
| Research Area | Immunology |Innate Immunity |Cytokine |Interleukins |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. IL13RA1/IL-13RA1 serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. IL13RA1/IL-13RA1 binds with low affinity to interleukin-13 (IL13). This subunit together with IL4RA can form a functional receptor for IL13. IL13RA1/IL-13RA1 also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. |
| Reference |