Mouse IL17RA / IL17R / CD217 Protein (Fc Tag)
AW538159,Cdw217,Il17r,VDw217
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| Catalog Number | P50328-M02H |
|---|---|
| Organism Species | Mouse |
| Host | Human Cells |
| Synonyms | AW538159,Cdw217,Il17r,VDw217 |
| Molecular Weight | The recombinant mouse IL17RA/Fc is a disulfide-linked homodimer. The reduced monomer comprises 532 amino acids and has a predicted molecular mass of 60.3 kDa. The apparent molecular mass of the protein is approximately 67-77 and 118 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| predicted N | Ser 32 |
| SDS-PAGE |  |
| Purity | (14.8+80.1) % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mouse IL17RA (Q60943)(Met1-Trp322) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | Measured by its binding ability in a functional ELISA. Immobilized mouse IL17A (P51065-MNAE) at 10 μg/ml (100 μl/well) can bind mouse IL17RA-Fc (cat: 50328-M02H), The EC50 of mouse IL17RA-Fc (cat: 50328-M02H) is 0.28-0.64 μg/ml. |
| Research Area | Immunology |Adaptive Immunity |T Cell |T Cell CD Antigen |CD Antigen (Helper T Cells) |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. |
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