Mouse IL1F8 / IL36b Protein
2310043N20Rik,Il36b,RP23-176J12.1
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| Catalog Number | P51071-MNAE |
|---|---|
| Organism Species | Mouse |
| Host | E. coli |
| Synonyms | 2310043N20Rik,Il36b,RP23-176J12.1 |
| Molecular Weight | The recombinant mouse IL1F8 consisting of 183 amino acids and has a calculated molecular mass of 21 kDa as estimated in SDS-PAGE under reducing conditions. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | > 96 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mouse IL1F8 (Q9D6Z6) (Met 1-Lys 183) was expressed. |
| Bio-activity | |
| Research Area | Neuroscience |Neurology process |Neurodegeneration and Neurodegenerative Disease |Multiple sclerosis |
| Formulation | Lyophilized from sterile 50mM Tris, pH 8.0 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contains a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includ four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-κB. |
| Reference |