Mouse IL1RL1 / ST2 Protein (Fc Tag)
DER4,Fit-1,Ly84,St2,St2-rs1,ST2L,T1,T1/ST2
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| Catalog Number | P51143-M02H |
|---|---|
| Organism Species | Mouse |
| Host | Human Cells |
| Synonyms | DER4,Fit-1,Ly84,St2,St2-rs1,ST2L,T1,T1/ST2 |
| Molecular Weight | The recombinant mouse ST2 comprises 544 amino acids and has a predicted molecular mass of 61.8 kDa. The apparent molecular mass of the protein is approximately 93.2 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| predicted N | Ser 27 |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mouse ST2 (NP_001020773.1) (Met1-Arg332) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Cancer |Invasion microenvironment |Angiogenesis |Cytokines / Chemokines in Angiogenesis |Interleukins |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines. |
| Reference |