Mouse JAM-A / F11R Protein (Fc Tag)
9130004G24,AA638916,ESTM33,JAM,JAM-1,JAM-A,Jcam,Jcam1,Ly106
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| Catalog Number | P50463-M02H |
|---|---|
| Organism Species | Mouse |
| Host | Human Cells |
| Synonyms | 9130004G24,AA638916,ESTM33,JAM,JAM-1,JAM-A,Jcam,Jcam1,Ly106 |
| Molecular Weight | The secreted recombinant mouse F11R/Fc is a disulfide-linked homodimeric protein. The reduced monomer comprises 457 amino acids and has a predicted molecular mass of 50.2 kDa. rmF11R/Fc monomer migrates as an is approximately 57 kDa band in SDS-PAGE under reducing conditions, with ~10% free Fc fragment. |
| predicted N | Lys 27 |
| SDS-PAGE |  |
| Purity | > 94 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mouse F11R (NP_766235.1) extracellular domain (Met 1-Ala 242) was fused with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Cardiovascular |Blood |Platelet |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1, involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily, JAM-A protein involves in platelet adhesion, secretion and aggregation, and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition, it may be a potential therapeutic target for breast cancer. |
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