Mouse LAMP2 / CD107b Protein (His Tag)

CD107b,Lamp-2,Lamp-2a,Lamp-2b,Lamp-2c,LampII,LGP-B,Mac3

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Catalog Number	P50791-M08H
Organism Species	Mouse
Host	Human Cells
Synonyms	CD107b,Lamp-2,Lamp-2a,Lamp-2b,Lamp-2c,LampII,LGP-B,Mac3
Molecular Weight	The secreted recombinant mouse LAMP2 comprises 365 amino acids and has a calculated molecular mass of 40.6 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 70-80 kDa band in SDS-PAGE under reducing conditions.
predicted N	Leu 26
SDS-PAGE
Purity	> 97 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the mouse LAMP2 (P17047-1) extracellular domain (Leu 26-Asn 379) was fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus.
Bio-activity
Research Area	Signaling |Signal Transduction |Metabolism |Pathways and Processes |Metabolism processes |Autophagy and mitophagy |
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	LAMP2 (Lysosomal-associated membrane protein 2), also known as CD107b (Cluster of Differentiation 107b), is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. In human, LAMP2, the causative gene of Danon disease, located on chromosome Xq24, encodes the lysosome-associated membrane protein-2 (LAMP-2). LAMP-2 deficiency, or Danon disease, is a rare X-linked lysosomal disease characterized by cardiomyopathy, vacuolar myopathy, and mental retardation. LAMP2 cardiomyopathy is an X-linked and highly progressive myocardial storage disorder associated with diminished survival, which clinically resembles sarcomeric hypertrophic cardiomyopathy.
Reference	Maron BJ, et al. (2010) Profound left ventricular remodeling associated with LAMP2 cardiomyopathy. Am J Cardiol. 106(8): 1194-6. Di Blasi C, et al. (2008) Danon disease: a novel LAMP2 mutation affecting the pre-mRNA splicing and causing aberrant transcripts and partial protein expression. Neuromuscul Disord. 18(12): 962-6. Echaniz-Laguna A, et al. (2006) Novel Lamp-2 gene mutation and successful treatment with heart transplantation in a large family with Danon disease. Muscle Nerve. 33(3): 393-7.