Mouse MFI2 / CD228 / melanotransferrin Protein (Fc Tag)

CD228,MTf

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Catalog Number	P50994-M02H
Organism Species	Mouse
Host	Human Cells
Synonyms	CD228,MTf
Molecular Weight	The secreted recombinant mouse MFI2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 930 amino acids and has a calculated molecular mass of 103 kDa. The apparent molecular mass of rmMFI2/Fc monomer is approximately 100 kDa in SDS-PAGE under reducing conditions.
predicted N	Val 20
SDS-PAGE
Purity	> 92 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the mouse MFI2 (Q9R0R1) (Met 1-Gln 708), without the propeptide, was fused with the Fc region of human IgG1 at the C-terminus.
Bio-activity
Research Area	Signaling |Signal Transduction |Metabolism |Types of disease |Metabolism in Cancer
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Richardson DR. (2000) The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell. Eur J Biochem. 267(5): 1290-8. Kim DK, et al. (2001) Serum melanotransferrin, p97 as a biochemical marker of Alzheimer's disease. Neuropsychopharmacology. 25(1): 84-90. Rothenberger S, et al. (1996) Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium. Brain Res. 712(1): 117-21. Baker EN, et al. (1992) Human melanotransferrin (p97) has only one functional iron-binding site. FEBS Lett. 298(2-3): 215-8.