Mouse Pleiotrophin / PTN / HB-GAM Protein (Fc Tag)
HARP,HB-GAM,HBBN,HBGF-8,HBNF,OSF,Osf-1,Osf1
- 100ug (NPP3456) Please inquiry
| Catalog Number | P51000-M01H |
|---|---|
| Organism Species | Mouse |
| Host | Human Cells |
| Synonyms | HARP,HB-GAM,HBBN,HBGF-8,HBNF,OSF,Osf-1,Osf1 |
| Molecular Weight | The recombinant mouse PTN/Fc is a disulfide-linked homodimer. The reduced monomer comprises 396 amino acids and has a calculated molecular mass of 43.7 kDa. The apparent molecular mass of the monomer is approximately 47 kDa in SDS-PAGE under reducing conditions. |
| predicted N | Glu |
| SDS-PAGE |  |
| Purity | > 85 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mouse PTN (P63089) (Gly 33-Asp 168) was fused with the Fc region of human IgG1 at the N-terminus. |
| Bio-activity | |
| Research Area | Immunology |Signal Transduction |Hormones |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damaged in the entorhinal cortex or in the substantia nigra pars compacta. It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin. HB-GAM binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. |
| Reference |